If the level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing the Demerol Injection dosage. If unacceptable opioid-related adverse reactions are observed, consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions. In severe overdose, particularly by the intravenous route, apnea, circulatory collapse, cardiac arrest, and death may occur. Do not increase your dose or take this medication more often than directed. Your condition will not improve any faster and your risk of serious side effects may be increased. acarbose online canada
Do 3 or 4 sets daily. Tolterodine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. They also stimulate prolactin, growth hormone GH secretion, and pancreatic secretion of insulin and glucagon. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. In case of overdose, priorities are the reestablishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures including oxygen and vasopressors in the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced life-support techniques.
Chronic use of opioids may cause reduced fertility in females and males of reproductive potential. The half-life of meperidine is 2 to 5 hours, and the half-life of normeperidine is 15 to 30 hours. Side Effects List Detrol LA side effects by likelihood and severity. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
Individually titrate Demerol Injection to a dose that provides adequate analgesia and minimizes adverse reactions. What should I avoid while taking tolterodine Detrol LA? Many drugs besides tolterodine may affect the heart rhythm QT prolongation including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics such as erythromycin among others. Then, if needed, she will order tests to get pictures of your kidneys and urinary tract.
When a patient who has been taking Demerol Injection regularly and may be physically dependent no longer requires therapy with Demerol Injection, taper the dose gradually, by 25% to 50% every 2 to 4 days, while monitoring carefully for signs and symptoms of withdrawal. If the patient develops these signs or symptoms, raise the dose to the previous level and taper more slowly, either by increasing the interval between decreases, decreasing the amount of change in dose, or both. Meperidine is metabolized through biotransformation. In vitro data show meperidine is metabolized to normeperidine in liver mainly by CYP3A4 and CYP2B6. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of Demerol Injection with serotonergic drugs. Consult your pharmacist for further advice. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day. If your symptoms do not improve or if they become worse, check with your doctor. Detrol LA extended-release capsules should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. Caution is advised when using Detrol LA extended-release capsules in CHILDREN; they may be more sensitive to its effects, especially an increased risk for urinary tract infection and behavior or attention problems. Methylprednisolone may also be used with other in hormone disorders. Cut back on sodium and salty foods: Lots of sodium can raise calcium levels in your urine. And that can cause stones to form. Swallow Detrol LA extended-release capsules whole. Do not break, crush, or chew before swallowing. If you are in really bad pain, you probably want to see a doctor. It repositions the urethra to help reduce leakage. There is a relationship between increasing meperidine plasma concentration and increasing frequency of dose-related opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory depression. Some medical conditions may interact with Detrol LA extended-release capsules.
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Blurred vision; constipation; dizziness; drowsiness; dry eyes; dry mouth; headache; indigestion; stomach pain. Long-term studies in animals to evaluate the carcinogenic potential of meperidine have not been conducted. This may not be a complete list of all interactions that may occur. Ask your health care provider if Detrol LA extended-release capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. The concomitant use of Demerol Injection with all cytochrome P450 3A4 inhibitors may result in an increase in meperidine plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in meperidine plasma concentration. Monitor patients for signs of urinary retention or reduced gastric motility when Demerol Injection is used concomitantly with anticholinergic drugs. Studies in animals to evaluate the mutagenic potential of meperidine have not been conducted. toradol
Demerol Injection may impair the mental or physical abilities needed to perform potentially hazardous activities such as driving a car or operating machinery. Warn patients not to drive or operate dangerous machinery unless they are tolerant to the effects of Demerol Injection and know how they will react to the medication. About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. HCl, and it has the following chemical structure. This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. The findings cannot be clearly attributed to maternal toxicity. This may interfere with certain laboratory tests such as possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Hold the squeeze for 10 seconds, then rest for 10 seconds. If any of these effects persist or worsen, tell your doctor or promptly. Butorphanol, nalbuphine, pentazocine, buprenorphine. If Demerol Injection is abruptly discontinued in a physically-dependent patient, a withdrawal syndrome may occur. Some or all of the following can characterize this syndrome: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis. Other signs and symptoms also may develop, including: irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate. Drowsiness and confusion can increase the risk of falling. buy nizoral indicacao nizoral
MAO inhibitors those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue. Alternatively, consider the use of non-opioid analgesics in these patients. Drug-seeking" behavior is very common in persons with substance use disorders. Drug-seeking tactics include emergency calls or visits near the end of office hours, refusal to undergo appropriate examination, testing, or referral, repeated "loss" of prescriptions, tampering with prescriptions, and reluctance to provide prior medical records or contact information for other treating health care providers. "Doctor shopping" visiting multiple prescribers to obtain additional prescriptions is common among drug abusers and people suffering from untreated addiction. Preoccupation with achieving adequate pain relief can be appropriate behavior in a patient with poor pain control. Meperidine causes a reduction in motility associated with an increase in smooth muscle tone in the antrum of the stomach duodenum. Digestion of food in the small intestine is delayed and propulsive contractions are decreased. Propulsive peristaltic waves in the colon are decreased, while tone may be increased to the point of spasm, resulting in constipation. Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. If any of these effects persists or worsens, tell your doctor or promptly. Demerol Injection, like other opioids, can be diverted for non-medical use into illicit channels of distribution. Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests, as required by state and federal law, is strongly advised. What are the possible side effects of tolterodine Detrol LA? The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with potent agonist opioids. Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing Demerol Injection. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity. This medication may lower your ability to fight infections. This may make you more likely to get a serious rarely fatal infection or make any infection you have worse. Overestimating the Demerol Injection dosage when converting patients from another opioid product can result in a fatal overdose with the first dose. Abuse and addiction are separate and distinct from physical dependence and tolerance. Health care providers should be aware that addiction may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. In addition, abuse of opioids can occur in the absence of true addiction. mentax brand name and price
What is the most important information I should know about tolterodine Detrol? Prolonged use of opioid analgesics during pregnancy may cause neonatal opioid withdrawal syndrome. Available data with Demerol Injection are insufficient to inform a drug-associated risk for major birth defects and miscarriage. Formal animal reproduction studies have not been conducted with meperidine. The safety and effectiveness of meperidine in pediatric patients has not been established. Literature reports indicate that meperidine has a slower elimination rate in neonates and young infants compared to older children and adults. Neonates and young infants may also be more susceptible to the effects, especially the respiratory depressant effects. If meperidine use is contemplated in neonates or young infants, any potential benefits of the drug need to be weighed against the relative risk of the patient. UpToDate: "Nutrition and Dietary Interventions in Adults with Inflammatory Bowel Disease. What should I avoid while taking tolterodine Detrol? Lifestyle changes and treatments can help with symptoms. Do NOT change your dose of Detrol LA extended-release capsules without checking with your doctor. Read the Patient Information Leaflet if available from your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. opux.info propecia
Do not share this medication with others. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Tell your doctor if your condition does not improve or if it worsens such as your remain high or increase. Oro Valley, AZ 85755. November 17, 2015. Drinking alcohol can increase some of the side effects of tolterodine. Tolterodine may cause a condition that affects the heart rhythm QT prolongation. Check the Rx Outreach website for the exact price and most current medication list. See "What Are Side Effects Associated with Using Tolterodine? Consult your doctor for specific advice. Meperidine is contraindicated in patients who are receiving monoamine oxidase MAO inhibitors or those who have recently received such agents. Therapeutic doses of meperidine have occasionally precipitated unpredictable, severe, and occasionally fatal reactions in patients who have received such agents within 14 days. The mechanism of these reactions is unclear, but may be related to a preexisting hyperphenylalaninemia. Some have been characterized by coma, severe respiratory depression, cyanosis, and hypotension, and have resembled the syndrome of acute narcotic overdose. Serotonin syndrome with agitation, hyperthermia, diarrhea, tachycardia, sweating, tremors and impaired consciousness may also occur. In other reactions the predominant manifestations have been hyperexcitability, convulsions, tachycardia, hyperpyrexia, and hypertension. Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations. It is not known whether this drug passes into milk. Consult your doctor before -feeding. MD, assistant professor of medicine, director, IBD Center, Georgetown University Hospital, Washington DC; expert, Crohn's amp; Colitis Foundation of America.
Squeeze the muscles that you use stop the flow of urine. Adults: The usual dosage is 50 mg to 150 mg intramuscularly or subcutaneously every 3 or 4 hours as needed for pain. Elderly patients should usually be given meperidine at the lower end of the dose range and observed closely. If concomitant use is necessary, consider increasing the Demerol Injection dosage until stable drug effects are achieved. Monitor for signs of opioid withdrawal. If a CYP3A4 or CYP2B6 inducer is discontinued, consider Demerol Injection dosage reduction and monitor for signs of respiratory depression. In patients with pheochromocytoma, meperidine has been reported to provoke hypertension. An extra patient leaflet is available with Detrol LA extended-release capsules. Talk to your pharmacist if you have questions about this information. Once you have passed the stone, the doctor will have it analyzed to figure out what it was made of. You also might need to collect your pee for 24 hours to have it tested. Advise both patients and caregivers about the risks of respiratory depression and sedation when Demerol Injection is used with benzodiazepines or other CNS depressants including alcohol and illicit drugs. Advise patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressant have been determined. Blunt cannulas should not be recapped, purposely bent or broken by hand. The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. These effects seem to be more prominent in ambulatory patients and in those who are not experiencing severe pain. In such individuals, lower doses are advisable. Some adverse reactions in ambulatory patients may be alleviated if the patient lies down. Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioid analgesics alone. How does your doctor know if you really do have a kidney stone? Tolterodine reduces spasms of the bladder muscles. Read the Patient Information Leaflet if available from your pharmacist before you start using tolterodine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. If any of these effects persist or worsen, notify your doctor or promptly. fosamax
These are the most common ones. What should I discuss with my healthcare provider before taking tolterodine Detrol? Monitor for signs of opioid withdrawal. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. What Are Warnings and Precautions for Tolterodine? tofranil australia pharmacy
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Do not use Demerol Injection in patients taking MAOIs or within 14 days of stopping such treatment. Americans, most of them women. There are several different types, causes, and treatments. Chronic use of opioids may influence the hypothalamic-pituitary-gonadal axis, leading to androgen deficiency that may manifest as low libido, impotence, erectile dysfunction, amenorrhea, or infertility. Meperidine, in 60 mg to 80 mg parenteral doses, is approximately equivalent in analgesic effect to 10 mg of morphine. The onset of action is slightly more rapid than with morphine, and the duration of action is slightly shorter. Meperidine is significantly less effective by the oral than by the parenteral route, but the exact ratio of oral to parenteral effectiveness is unknown. buy maxalt china
Demerol Injection exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Elevated serum levels have been reported to cause central nervous system excitatory effects. Meperidine should therefore be used with caution in patients with hepatic impairment. Titrate the dosage of Demerol Injection slowly in patients with hepatic impairment and monitor closely for signs of central nervous system and respiratory depression. Prescription drug abuse is the intentional non-therapeutic use of a prescription drug, even once, for its rewarding psychological or physiological effects. Woosley RL, Romero KA. www. Check the labels on all your medicines such as allergy or cough-and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Inadvertent injection about a nerve trunk may result in sensory-motor paralysis which is usually, though not always, transitory. Do not use Demerol Injection in patients taking MAOIs or within 14 days of stopping such treatment. Intravenous hydrocortisone or prednisolone have been used to treat severe reactions, with the addition of intravenous chlorpromazine in those cases exhibiting hypertension and hyperpyrexia. The usefulness and safety of narcotic antagonists in the treatment of these reactions is unknown. Detrol LA extended-release capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people. The concomitant use of acyclovir may increase the plasma concentrations of meperidine and its metabolite, normeperidine. Report prolonged or to your doctor. Reserve concomitant prescribing of Demerol Injection and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate. Follow patients for signs and symptoms of respiratory depression and sedation. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Your doctor may occasionally change your dose to make sure you get the best results. persantine
UpToDate: "Management of Mild to Moderate Ulcerative Colitis, "Nutrition and dietary interventions in adults with inflammatory bowel disease. Prolonged use of Demerol Injection during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly. Tell your doctor if your condition does not improve or if it worsens. First, you complete a chart of the times you pee and the times you leak. You observe patterns and then plan to empty your bladder before an accident would happen. You can also "retrain" your bladder, gradually increasing the time between bathroom visits. Kegel exercises are also helpful. Concomitant use of Demerol Injection with CYP3A4 inducers or discontinuation of a CYP3A4 inhibitor could decrease meperidine plasma concentrations, decrease opioid efficacy or, possibly, lead to a withdrawal syndrome in a patient who had developed physical dependence to meperidine. What other drugs will affect tolterodine Detrol? Demerol Injection contains meperidine, a Schedule II controlled substance. Concomitant use of Demerol Injection with monoamine oxidase MAO inhibitors can result in coma, severe respiratory depression, cyanosis, and hypotension.
Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Parenteral drug abuse is commonly associated with transmission of infectious diseases such as hepatitis and HIV. Kathleen Zelman, MPH, RD, Director of Nutrition, WebMD. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. The treatment takes about an hour, and you can usually go home about an hour later. If concomitant use is necessary, consider dosage reduction of Demerol Injection until stable drug effects are achieved. Monitor patients for respiratory depression and sedation at frequent intervals. The following adverse reactions associated with the use of meperidine were identified in clinical studies or postmarketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Swallow this medication with the help of liquids. not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or tells you to do so. Swallow the whole or split tablet without crushing or chewing. There are many other drugs that can interact with tolterodine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. lexapro pills purchase online shop
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Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines such as cetirizine, diphenhydramine drugs for sleep or anxiety such as alprazolam, diazepam, zolpidem muscle relaxants, and narcotic pain relievers such as codeine. Meperidine and normeperidine are excreted by kidneys. PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Detrol LA extended-release capsules while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Detrol LA extended-release capsules. zyprexa
To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated while using this drug, consult your pharmacist for help in selecting a laxative such as a stimulant-type with stool softener. Demerol Injection is indicated for preoperative medication, support of anesthesia, and obstetrical analgesia. Check with your pharmacist about how to dispose of unused medicine.
Neonatal opioid withdrawal syndrome presents as irritability, hyperactivity and abnormal sleep pattern, high pitched cry, tremor, vomiting, diarrhea, and failure to gain weight. The onset, duration, and severity of neonatal opioid withdrawal syndrome vary based on the specific opioid used, duration of use, timing and amount of last maternal use, and rate of elimination of the drug by the newborn. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.
Have your checked regularly while taking this medication. Learn how to monitor your own pressure at home, and share the results with your doctor. Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. Warn patients of the symptoms of serotonin syndrome and to seek medical attention right away if symptoms develop. Meperidine should therefore be used with caution in patients with renal impairment. Titrate the dosage of Demerol Injection slowly in patients with renal impairment and monitor closely for signs of central nervous system and respiratory depression.